ABSTRACT
ABSTRACT Infantile hemangioma, the most common benign tumor in infancy, is usually an isolated condition occurring in many different locations in the body. However, large infantile hemangioma may be associated with other systemic malformations, including central nervous system, cerebrovascular, cardiac, and ophthalmology abnormalities, a condition termed PHACE syndrome. In this paper, we describe a case of PHACE syndrome that was presented with the unique association of a large facial infantile hemangioma and morning glory anomaly.
RESUMO O hemangioma infantil é a causa mais comum de tumor benigno na infância e usualmente é uma condição isolada podendo ocorrer em diferentes regiões do corpo. No entanto, hemangiomas infantil extensos podem ser associados com outras malformações sistêmicas incluindo anomalias no sistema nervoso central, cerebrovasculares, cardíacas e oftalmológicas, uma condição denominada síndrome PHACE. Neste trabalho, descrevemos o caso de um paciente com síndrome PHACE que se apresentou com um extenso hemangioma facial e anomalia de "morning glory".
Subject(s)
Humans , Infant , Aortic Coarctation/complications , Abnormalities, Multiple , Eye Abnormalities/complications , Neurocutaneous Syndromes/complications , Eye Neoplasms/complications , Hemangioma , Abnormalities, Multiple/diagnosis , Eye Abnormalities/diagnosis , Eye Neoplasms/diagnosis , Hemangioma/complications , Hemangioma/diagnosisSubject(s)
Humans , Eye Neoplasms/diagnosis , Eye Neoplasms/therapy , Brazil , Public Health , Telemedicine , Mobile Applications , SmartphoneABSTRACT
Abstract We report a case of primary bilateral mucosa associated lymphoid tissue (MALT) lymphoma of the lacrimal sac. MALT lymphoma is a subtype of Non-Hodgkin's Lymphoma of the ocular adnexa. When the primary site of the lymphoma is the lacrimal sac, it mimics chronic dacryocystitis. This may delay diagnosis, with potentially lethal results.
Resumo Descrevemos um caso de um linfoma MALT bilateral, simétrico e primário de saco lacrimal. O linfoma MALT é um subtipo do Linfoma Não-Hodkin dos anexos oculares. Quando o local primário do linfoma é o saco lacrimal, ele pode simular uma dacriocistite crônica. Essa situação pode atrasar o diagnóstico e ter consequências fatais.
Subject(s)
Humans , Male , Middle Aged , Lymphoma, B-Cell, Marginal Zone/diagnosis , Eye Neoplasms/diagnosis , Lacrimal Apparatus Diseases/diagnosis , Biopsy , Magnetic Resonance Imaging , Chlorambucil/therapeutic use , Lymphoma, B-Cell, Marginal Zone/pathology , Lymphoma, B-Cell, Marginal Zone/therapy , Eye Neoplasms/therapy , Rituximab/therapeutic use , Lacrimal Apparatus Diseases/therapyABSTRACT
Objetivo: reportar los casos de dos pacientes con metástasis coroideas y a nervio óptico secundarias a carcinoma ductal infiltrante mamario y revisar la literatura al respecto. Diseño del estudio: estudio observacional descriptivo, tipo serie de casos. Metodología: se reporta el caso de dos pacientes con diagnóstico de metástasis coroidea y a nervio óptico secundarias a carcinoma mamario que consultaron a la Liga de Lucha Contra el Cáncer en Barranquilla Colombia en Enero del 2015 y a la Clínica Unidad Láser del Atlántico en Agosto de 2014. Se hizo revisión detallada de la historia clínica, se tomaron fotos a color, angiografía con fluoresceína de la retina, ecografía y tomografía óptica coherente de mácula y nervio óptico Resultados: Serie de dos casos de metástasis oculares de carcinoma mamario. Mujeres de 41 y 52 años con diagnóstico conocido de carcinoma mamario que requirió mastectomía radical y quimioterapia sistémica. Los estudios de angiografía y ecografía confirmaron la impresión diagnóstica clínica de metástasis intraocular. Conclusión: los tumores metastásicos son las neoplasias malignas intraoculares más comunes en el adulto y la coroides es el lugar más frecuente donde ocurren, siendo las metástasis a nervio óptico un evento infrecuente. Se recomienda una evaluación periódica por retina y un alto índice de sospecha diagnóstica en aquellos pacientes con diagnóstico conocido de carcinoma mamario con o sin metástasis sistémicas asociadas, que inician con síntomas visuales. En estos casos las pruebas auxiliares como ecografía modo B y angiografía son herramientas útiles para apoyar el diagnóstico.
Objective: to report two cases of choroidal and optic nerve metastases from breast carcinoma and review the literature. Design: cases reports. Methods: We performed a descriptive case report with detailed review of the medical records of two patients with intraocular metastasis from breast carcinoma. Their medical records were reviewed and analyzed. Ultrasonography, fluorescein angiography and optic coherence tomography were taken. Results: We report a series of two women 41 and 52 years old with a previous diagnosis of infiltrating ductal carcinoma that required radical mastectomy and systemic chemotherapy. Angiography and ultrasound studies confirmed the clinical diagnosis of intraocular metastases. Conclusions: metastatic carcinomas are the most common forms of adult intraocular tumors and the choroid is the most frequent site where they occur. Metastases to the optic nerve head are rare event. Periodic visits to the retina specialist and a high index of suspicion in patients with visual symptoms and diagnosis of breast carcinoma with or without associated systemic metastasis are recommended. Angiography and ultrasonography are important ancillary tools.
Subject(s)
Eye Neoplasms/diagnosis , Breast Neoplasms , Neoplasm Metastasis/diagnosis , Retinal Diseases/diagnosisABSTRACT
Objetivos: presentar el caso de una paciente que desarrolló un neurofibroma solitario de localización cantal interna. Diseño de estudio: reporte de caso. Métodos: se reporta el caso de una paciente con un neurofibroma solitario localizado en el canto interno, a la vez que se presenta una breve revisión bibliográfica sobre esta patología infrecuente. Conclusiones: el neurofibroma solitario es una patología infrecuente de naturaleza benigna que puede comprometer el globo ocular, el párpado y la órbita, por lo que debe ser considerado dentro de los diagnósticos diferenciales de la patología tumoral de estas áreas anatómicas.
Objectives: to report the case of a patient with a solitary neurofibroma in the medial canthal area. Study design: case report. Methods: report the case of a patient with a solitary neurofibroma in the medial canthal area and review the pertinent literature. Conclusions: the solitary neurofibroma is a rare benign condition with the potential to compromise the eye, the eyelid and the orbit, so that should be considered in the differential diagnosis of tumoral pathology in these anatomic areas. Keywords: nerve sheath neoplasms, peripheral nervous system neoplasms, neurofibroma.
Subject(s)
Neurofibroma/therapy , Eye Neoplasms/diagnosis , Ophthalmologic Surgical Procedures , Peripheral Nerves/pathologyABSTRACT
No abstract available.
Subject(s)
Aged , Female , Humans , Biopsy , Carcinoma, Squamous Cell/diagnosis , Dacryocystorhinostomy/adverse effects , Eye Neoplasms/diagnosis , Lacrimal Apparatus/pathology , Lacrimal Apparatus Diseases/diagnosis , Postoperative Complications , Tomography, X-Ray ComputedABSTRACT
No abstract available.
Subject(s)
Female , Humans , Middle Aged , Bone Marrow/pathology , Carcinoma, Adenoid Cystic/diagnosis , Eye Neoplasms/diagnosis , Lacrimal Apparatus/pathology , Lacrimal Apparatus Diseases/diagnosis , Maxilla , Neoplasm Invasiveness , Neoplasm Recurrence, Local , Positron-Emission Tomography , Tomography, X-Ray ComputedABSTRACT
PURPOSE: The incidence and clinical correlation of MALT1 translocation and chromosomal numerical aberrations in Korean patients with ocular adnexal mucosa associated lymphoid tissue (MALT) lymphoma have not yet been reported. We investigated the incidence and clinicopathologic relationship of these chromosomal aberrations in ocular adnexal MALT lymphomas in a Korean population. METHODS: Thirty ocular adnexal MALT lymphomas were investigated for the t(11;18) API2-MALT1, t(14;18) IgH-MALT1 translocations and chromosomes 3 and 18 aneuploidies using fluorescence in situ hybridization. Patient medical records were reviewed retrospectively for information on demographics and clinical characteristics, including treatment response. RESULTS: The MALT1 gene rearrangement was found in one out of 30 cases. The t(14;18) IgH-MALT1 translocation was demonstrated in only one case (3.3%), and the t(11;18) API2-MALT1 translocation was not found in any of the cases. Trisomy 3 was observed in three ocular adnexal MALT lymphomas (10.0%), and five cases showed trisomy 18 (16.7%). Translocation positive cases also showed trisomy 18. One case of tumor relapse showed trisomy 18 only in the recurrent biopsies. There were no statistically significant correlations between chromosomal aberrations and clinical characteristics and treatment responses. CONCLUSIONS: Translocations involving the MALT1 gene are not common in Korean ocular adnexal MALT lymphomas. The t(14;18) translocation was detected in only one out of 30 cases, and the t(11;18) translocation was not found at all. Furthermore, the chromosomal aberrations found in this study had no prognostic implications.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Chromosome Aberrations , Chromosomes, Human, Pair 14 , Chromosomes, Human, Pair 18/genetics , Eye Neoplasms/diagnosis , In Situ Hybridization, Fluorescence , Incidence , Lymphoma, B-Cell, Marginal Zone/diagnosis , Republic of Korea/epidemiology , Translocation, GeneticABSTRACT
Objetivo: determinar la validez de la citología de impresión en lesiones conjuntivales clínicamente sospechosas de neoplasia comparada con la histopatología. Diseño: estudio de prueba diagnóstica. Métodos: pacientes que ingresaron a la Fundación Oftalmológica Nacional de Colombia con diagnóstico clínico de neoplasia de superficie ocular o lesión sospechosa de neoplasia quienes fueron sometidos a citología de impresión y posterior resección quirúrgica completa más estudio patológico de la lesión. Resultados: se examinaron 54 pacientes de los cuales 27 fueron mujeres y 27 hombres correspondiendo a 50% en cada grupo. La media de edad fue 52.3 años. La lesión más frecuente fue la neoplasia conjuntival escamosa intraepitelial (NIC) en los diagnósticos clínico, citológico y patológico. Se encontró que la sensibilidad de la citología de impresión fue de 92.86% y la especifi cidad de 50%. Con respecto al diagnóstico clínico relacionado con la patología se obtuvo una sensibilidad de 92.86% y una especificidad de 80.77%. Conclusiones: Se encontró que la citología de impresión es una prueba sensible mas no específica para el tamizaje de neoplasias de superficie ocular, sin embargo no muestra una superioridad frente a un buen diagnóstico clínico. Se debe aclarar que son observaciones preliminares de un estudio que se encuentra en curso.
Objective: to determine impression cytology validity for conjunctival malignant lesions compared to pathology. Design: diagnostic test study. Methods: patients admitted to Fundación Oftalmológica Nacional of Colombia with clinical diagnosis of ocular surface neoplasia or suspicious ocular surface neoplasia who underwent impression cytology before excisional surgery of the lesion and pathologic study. Results: fifty four patients were obtained for this initial analysis, 27 were of female sex and 27 males, each group corresponded to 50%. Mean age obtained was 52.3 years. The most frequent lesion found was ocular surface squamous cell neoplasia in the clinical diagnosis, impression cytology and pathology. Impression cytology sensitivity found is 92.86% and 50% of specificity. Clinical diagnosis was found to have 92.68% sensitivity and 80.77% Conclusions: impression cytology was found to be a sensitive test but not specific, which is adequate for a screening test, however it does not demonstrate to be superior to a clinical diagnosis made by a trained specialist. It must be clear that these are preliminary observations and calculations of a study that is still in course and the sample is incomplete.
Subject(s)
Conjunctival Neoplasms/diagnosis , Cytological Techniques/methods , Eye Neoplasms/diagnosisABSTRACT
Objetivos: evaluar la concordancia entre la citología de impresión y el estudio de anatomía patológica en pacientes con nevus conjuntivales que consultaron al Departamento de Córnea de la Clínica Oftalmológica de Cartagena. Diseño del estudio: estudio de concordancia. Métodos: se tomaron 48 ojos de 44 pacientes con hiper o hipopigmentación conjuntival a los que se le realizó citología de impresión y estudio histopatológico comparándose los resultados. Resultados: durante Junio 2011 a Junio 2012 se incluyeron 48 pacientes con sospecha de nevus conjuntivales a los cuales se les realizó citología de impresión y estudio histopatológico. Tuvo más prevalencia el sexo femenino con 68.75%. La edad promedio fué de 34.5 años. Las lesiones encontradas en OD fueron el 52.08%. El 60.42% presentaron pigmento leve o moderado seguido de un 35.42% de pacientes con abundante pigmentación. La localización más común de la lesión fue la conjuntiva bulbar con 93.75%. La citología de impresión resultó positiva para nevus en el 89.58% mientras que la patología arrojó resultados de nevus sub-epitelial en un 35.42%, seguido de nevus compuesto y de unión en el 33.33 y 20.83% respectivamente, y ausencia de nevus en el 10.42%. La sensibilidad de la citología de impresión fue de 93.02% con una especificidad del 40%. Conclusiones: la citología de impresión es un método altamente sensible para la detección de nevus conjuntivales y puede ser utilizado como prueba de tamizaje.
Objectives: to evaluate the concordancebetween impression cytology and pathology evaluation in patients with conjunctival nevus attending Cornea Clinic at Clinica Oftalmológica de Cartagena. Study Design: concordance study Methods: We evaluated 48 eyes from 44 patients with conjunctival hyper or hypopigmentation whom underwent impression cytology and histopathology assessment to find concordance between two methods. Results: during June 2011 to June 2012, we included 48 patients with suspected conjunctival nevus whom underwent impression cytology and histopathology study. Female prevalence was 68.75%. Average age was 34.5 years. Lesions were found in right eye in 52.08% of patients. 60.42% had moderate or mild pigment followed by 35.42% with abundant pigment. The most common location of injury was the bulbar conjunctiva with 93.75%. Impression cytology was positive for nevus in 89.58%, while pathology studies showed subepithelial nevus in 35.42% of cases, followed by compound nevus and union nevus with 33.33% and 20.83% respectively. 10.42% of patients showed absence of nevus. Sensitivity of impression cytology was 93.02% while specificity of the test achieved 40%. Conclusions: impression cytology is a highly sensitive method to detect conjunctival nevi and can be used as a screening test.
Subject(s)
Eye Neoplasms/diagnosis , Cell Biology/trends , Diagnostic Techniques, Ophthalmological/trends , Nevus/diagnosisABSTRACT
A myxoma is a benign tumor found in the heart and in various soft tissues; however, a corneal myxoma is rare. A mucinous mass of unknown etiology was observed on the left cornea of a 32-year-old male patient. We performed deep anterior lamellar keratoplasty using acellular corneal tissue and concurrent amniotic membrane transplantation. Hematoxylin and eosin staining revealed vacuolation of the parenchyma and myxoid change in the corneal tissue that occurred in the anterior half of the corneal parenchyma. We identified a myxoid stroma by Alcian blue staining and observed collagen fibers with denatured stroma by Masson trichrome staining. The patient's visual acuity improved from light perception to 20 / 200, and the intraocular pressure remained within the normal range for one year after surgery. The transplanted cornea survived successfully with well-maintained transparency, and recurrence was not observed one year after surgery.
Subject(s)
Adult , Humans , Male , Cornea , Corneal Stroma/cytology , Corneal Transplantation/methods , Eye Neoplasms/diagnosis , Myxoma/diagnosisABSTRACT
A myxoma is a benign tumor found in the heart and in various soft tissues; however, a corneal myxoma is rare. A mucinous mass of unknown etiology was observed on the left cornea of a 32-year-old male patient. We performed deep anterior lamellar keratoplasty using acellular corneal tissue and concurrent amniotic membrane transplantation. Hematoxylin and eosin staining revealed vacuolation of the parenchyma and myxoid change in the corneal tissue that occurred in the anterior half of the corneal parenchyma. We identified a myxoid stroma by Alcian blue staining and observed collagen fibers with denatured stroma by Masson trichrome staining. The patient's visual acuity improved from light perception to 20 / 200, and the intraocular pressure remained within the normal range for one year after surgery. The transplanted cornea survived successfully with well-maintained transparency, and recurrence was not observed one year after surgery.
Subject(s)
Adult , Humans , Male , Cornea , Corneal Stroma/cytology , Corneal Transplantation/methods , Eye Neoplasms/diagnosis , Myxoma/diagnosisABSTRACT
A 36-year-old woman was diagnosed with anaplastic large cell lymphoma (ALCL) by excisional biopsy of a left frontal skin lesion. During the first cycle of chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone), the patient complained of right ocular pain and inflammation. Cytologic examination using aqueous humor revealed atypical lymphocytes, suggesting intraocular ALCL involvement. Acute angle closure developed in the anterior chamber due to rapid progression of ALCL, causing pupillary block. Laser and surgical interventions were attempted but failed to relieve the pupillary block. Finally, radiation therapy resolved the pupillary block to restore the anterior chamber and normalize intraocular pressure. This is the first case in the English literature of ALCL involving the iris to cause acute secondary angle closure.
Subject(s)
Adult , Female , Humans , Anterior Eye Segment/pathology , Biopsy , Diagnosis, Differential , Eye Neoplasms/diagnosis , Lymphoma, Large-Cell, Anaplastic/diagnosis , Magnetic Resonance Imaging , Neoplasm Invasiveness , Positron-Emission TomographyABSTRACT
A 36-year-old woman was diagnosed with anaplastic large cell lymphoma (ALCL) by excisional biopsy of a left frontal skin lesion. During the first cycle of chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone), the patient complained of right ocular pain and inflammation. Cytologic examination using aqueous humor revealed atypical lymphocytes, suggesting intraocular ALCL involvement. Acute angle closure developed in the anterior chamber due to rapid progression of ALCL, causing pupillary block. Laser and surgical interventions were attempted but failed to relieve the pupillary block. Finally, radiation therapy resolved the pupillary block to restore the anterior chamber and normalize intraocular pressure. This is the first case in the English literature of ALCL involving the iris to cause acute secondary angle closure.
Subject(s)
Adult , Female , Humans , Anterior Eye Segment/pathology , Biopsy , Diagnosis, Differential , Eye Neoplasms/diagnosis , Lymphoma, Large-Cell, Anaplastic/diagnosis , Magnetic Resonance Imaging , Neoplasm Invasiveness , Positron-Emission TomographyABSTRACT
In a meeting of the Pan-American Association of Ophthalmic Pathology, held in Los Angeles, CA, on October 10, 1991, at the Doheny Eye Institute, C.O. Degrazia proposed the name LOFONEUROGONIOMA for a single undifferentiated intraocular tumor originated in the cells of lamina fusca, with undifferentiated cells of expressive differentiation into Schwann cell, melanoblast and neuroendocrine cell lineages. In view of trimorphism, a pathologist may be led to a diagnosis of malignant melanoma, schwannoma or endocrine cell tumor. After this date, an article was published in Revista da AMRIGS, Porto Alegre, 52 (4): 261-272, oct-dec 2008, with collaboration of experts from the fields of Immunohistochemistry and electron microscopy. The current publication is the third one and its main purpose is to highlight the original characteristics of such a tumor.
Na reunião da Associação Pan-americana de Patologia Oftálmica, realizada em Los Angeles CA, 10 de Outubro de 1991, no DOHENY EYE INSTITUTE, C.O. Degrazia propôs o nome de LOFONEUROGONIOMA para um tumor solitário intraocular, indiferenciado, originado nas células da lâmina fusca, com células indiferenciadas de expressiva diferenciação para a linhagem schwannoblástica, melanoblástica e neuroendócrina. Em face do trimorfismo, o patologista pode ser conduzido para os diagnósticos de melanoma, schwannoma malignos, ou tumor de células endócrinas. Foi feita após essa data uma publicação na Revista da AMRIGS. Porto Alegre, 52 (4): 261-272, out.-dez 2008, na qual consta a lista dos colaboradores. A publicação atual é a terceira, tendo como finalidade principal colocar em relevo as originalidades de semelhante tumor.
Subject(s)
Humans , Sclera/ultrastructure , Eye Neoplasms/diagnosis , Neural CrestABSTRACT
We report a case of intraocular lymphoma in a 65-year-old man, 15 months after cardiac transplantation. On Magnetic Resonance (MR) images, the iris and the anterior chamber of the right eye were found to be involved with an enhancing soft-tissue lesion. To our knowledge, this is the first case of post-transplantation intraocular lymphoma evaluated with MR imaging.
Subject(s)
Humans , Male , Middle Aged , Cardiomyopathies/surgery , Diabetes Mellitus, Type 2/complications , Diagnosis, Differential , Eye Neoplasms/diagnosis , Fatal Outcome , Heart Transplantation , Lymphoma/diagnosis , Magnetic Resonance Imaging/methodsABSTRACT
Herein, we report a case of nasal natural killer T-cell lymphoma (NKTL) with intraocular involvement. A 57-year-old woman was referred due to a three-day history of photophobia and diplopia in the left eye. One-month previously, she was diagnosed with nasal NKTL of the right nasal cavity. Ophthalmic examination revealed conjunctival injection and ptosis. The left pupil was fully dilated and non-reactive to light. Ocular motion was restricted on left-upper gaze. Five days later, anterior uveitis developed and persisted despite topical steroid treatment. An orbital magnetic resonance imaging was without specific findings, however, ophthalmoplegia, vitreous opacity, and an iris mass were observed. A diagnostic anterior chamber aspiration was performed. Aqueous humor aspiration revealed 35% morphologically atypical lymphocytes. After an intravitreal triamcinolone injection, radiotherapy and chemotherapy were administered; this resolved the uveitis and iris mass. When refractory uveitis or orbital pseudotumor occurs in patients with nasal NKTL, ocular and orbital involvement of the NKTL should be considered.
Subject(s)
Female , Humans , Middle Aged , Diagnosis, Differential , Eye Neoplasms/diagnosis , Fatal Outcome , Lymphoma, T-Cell/pathology , Magnetic Resonance Imaging , Natural Killer T-Cells/pathology , Nose Neoplasms/pathologyABSTRACT
We report a rare presentation of an initially misdiagnosed case of a pseudotumor, which on histopathology was diagnosed as bilateral breast metastases of lobular carcinoma involving multiple extraocular muscles. A 61-year-old lady presented with external ophthalmoplegia and diplopia. Incisional biopsy was performed using a lid crease approach and the patient received radiotherapy and hormonal therapy. Following prolonged hormonal therapy, complete remission was achieved, with improvement in ocular motility and resolution of diplopia, about 18 months after the initial presentation. Multiple extraocular muscle involvement by breast carcinoma metastasis is very rare and should be considered in the differential diagnosis, especially in patients with a prior history of breast carcinoma.
Subject(s)
Biopsy , Breast Neoplasms/pathology , Breast Neoplasms/therapy , Carcinoma, Lobular/diagnosis , Carcinoma, Lobular/secondary , Carcinoma, Lobular/therapy , Combined Modality Therapy , Diagnosis, Differential , Eye Neoplasms/diagnosis , Eye Neoplasms/secondary , Eye Neoplasms/therapy , Female , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Middle Aged , Muscle Neoplasms/diagnosis , Muscle Neoplasms/secondary , Muscle Neoplasms/therapy , Neoplasm Staging , Oculomotor Muscles , Time FactorsABSTRACT
To report a case of bilateral primary intraocular lymphoma. A 33-year-old man presented with bilateral blurred vision since two years ago. Examination revealed large keratic precipitates, anterior chamber reaction, posterior subcapsular cataracts, and vitreous infiltration. After a short trial of topical and periocular steroids, diagnostic 25-gauge pars plana vitrectomy was performed and cytologic evaluation of the aspirate confirmed a diagnosis of intraocular lymphoma. The patient was subsequently managed with intravitreal methotrexate in both eyes and responded favorably. Central nervous system workup for lymphoma was negative. Primary intraocular lymphoma should be considered in young adults suffering from chronic recalcitrant panuveitis
Subject(s)
Humans , Male , Eye Neoplasms/diagnosis , Immunohistochemistry , Diagnosis, Differential , Lymphoma, B-Cell/diagnosis , Drug Therapy, Combination , Antigens, CD20 , Early Diagnosis , Retinal VasculitisABSTRACT
O câncer de mama metastático para o olho é incomum e de mau prognóstico, sendo frequentemente associado à metastase do sistema nervoso central (SNC). A diminuiçao progressiva da acuidade visual é o sintoma mais marcante. Apresentar-se o caso de uma paciente com cancer de mama confirmado por histopatológico - carcinoma ductal invasivo (CDI) - e com estadiamento inicial T3N1M0 (EC III). Realizaram-se quimioterapia neoadjuvante e mastectomia radical. Ressonância magnética realizada após o início de dor na região ocular esquerda mostrou imagem na fossa posterossuperior da órbita ipsilateral. A imunoistoquímica, após procedimento neurocirúrgico, estabeleceu diagnóstico de metástase cerebral, primária da mama. A paciente permanece estável e em seguimento até o momento.
Metastatic breast cancer is uncommon to the eye and hard to be prognosticated. It is frequently associated to metastasis of the central nervous system (CNS). The most present symptom is the progressive loss of the visual perceptiveness. We presented a patient case with breast cancer confirmed by histopathological - invasive ductal carcinoma (IDC) - initial stage T3N1M0 (EC III). Neoadjuvant chemotherapy and radical mastectomy procedure were realized. The magnetic resonance carried out after the ache at the left ocular region showed image of the posterior superior fossa of the ipsilateral orbit. The immohistochemistry, after neurosurgical procedure, determined brain metastasis diagnosis, primary of the mamma. The patient remains stable and in positive process.